Friday, March 1, 2019

The Safety of Graviola

Every couple of years someone publishes a research paper saying graviola causes neurotoxicity or the main anticancer chemical, annonacin, is a neurotoxin and it’s unsafe to take graviola supplements. I’m going to share my personal experience and provide you with my educated opinion of these studies and let you decide for yourself whether graviola is dangerous to take.  These are my opinions only, based on my research and my personal experience… do with it what you will and make your own decisions about your own health.

I’m writing this quickly without going back to completely review all these old studies. I just don’t have the time right now, so am going to summarize. The very first study reporting the neurotoxicity of graviola extracted graviola in methanol or ethanol (don’t remember which) and injected directly into some lab animals’ brains (mice or rats). This study reported graviola was a neurotoxin because it caused cell death in the brain. At the time, I said okay… my customers buying graviola weren’t injecting their supplements into their brain, so no worries.  I knew lots of stuff, even just the methanol, would cause cell death if it were directly injected into the brain. I also knew this certainly did NOT prove graviola could make it over the blood-brain barrier into the brain in the same fashion when it was ingested orally.

Then this isolated, economically disadvantaged community in the West Indies (Guadeloupe) came down with some unexplained Parkinson’s Disease-like symptoms (trembling, shaking, tics, etc.). They were interviewed about what was in their diet, looking for what that might be a dietary/environmental cause. Like most people in the tropics, graviola fruit was in their diet, and they also used a graviola leaf tea as an herbal remedy occasionally when needed. They weren’t eating or drinking both daily. The researchers assumed (or wanted to believe) it was the graviola because of the previous “neurotoxic” study which injected graviola into the brain. They did another study “to prove it,” this time injecting just a graviola chemical called annonacin into the brains of lab animals. They again reported cell death, especially to certain dopamine-type brain cells which might possibly cause  some of the same sort of symptoms (lack of dopamine causes/worsens Parkinson’s). In this study they reported graviola causes Parkinson’s-like symptoms because it has neurotoxic compounds and cautioned people not to take it. They, of course, never determined graviola compounds and annonacin specifically were actually in the brains of these people or proved it was graviola that caused their shaking – it was still just a correlation or possible link based on a dietary questionnaire when they published this study.

A while later is was determined that the diet of these people were nutritionally deficient and that was the cause of their symptoms. I think is was several of the B vitamins severely lacking, but won’t take the time to go back and look it up. They cured these people of their Parkinson’s-like symptoms by fixing the nutritional deficiency (not by removing graviola from their diets). But for years, graviola was attributed with this incorrect link and a warning that graviola might cause Parkinson’s-like symptoms because of “possible neurotoxicity.” I’m STILL seeing this incorrect association in some of the research they’ve continued to publish trying to somehow prove graviola is somehow unsafe and is neurotoxic and the science gets even more convoluted trying to prove this concept.

Convoluted? My opinion of course, but let me give you an example. In 2015 they published a research paper that reported: “These results demonstrate that the intake of dietary supplements containing plant material from Annonaceae may be hazardous to health in terms of neurotoxicity.” Based on what? On an in vitro (test tube) study. First, they extracted 3 different Anonna plants (including graviola) in hot, pressurized, ethyl acetate (a toxic, flammable chemical you have to wear protective equipment to handle) Logically, nothing like what happens when you take some leaf capsules or leaf tea by mouth and it goes through digestion, right? What gets “extracted” in your stomach logically isn’t what gets extracted under heat and pressure in a toxic chemical that’s found in your nail polish remover that strips polymers off your nails. Right? Logically, speaking of course.

Then they put some “brain cells” in some little cup holders/wells. But they didn’t really use brain cells, they used “Lund human mesencephalic neurons.” You purchase these from a lab that grows them and sells them for research purposes. These are actually undeveloped, precursor brain cells that came from an 8 week old human embryo/fetus. Logically, these cells are not present in your brain or mine, and I’m assuming they’d be a tad more delicate than a fully formed brain cell. That’s an assumption, I haven’t bothered to look it up. So, they mixed these fetal precursor cells directly with this toxic-nail-polisher-remover graviola extract in the little cup holders, waited 48 hours and said: “Wow, this extract killed 67% of these delicate precursor cells!” Therefore, Annona plants are neurotoxic and taking a graviola/Annona supplement is harmful for you to take. Huh? Wait. What?

Personally, I’m not worried that what I eat or drink is going to be digested and extracted in the same manner as they extracted it. I won’t be washing my supplements down with nail polish remover either. I don’t logically think it will be absorbed in my bloodstream thru normal digestion in the same manner and somehow make it thru my blood-brain barrier meant to keep most things out of my brain.  I don’t logically think it will come in direct contact with my brain cells like it did in the little cup holders and have the same effect they demonstrated in this study. But hey, that’s me. I’m way logical, and now that you have the facts about this study, you can draw your own conclusions.

I think if I sold about a million bottles of graviola supplements over 15 years (which I did) and was killing 67% of my customer’s brain cells in one dose, someone would have said something. They didn’t, and graviola didn’t. Also, never once, did we get any report of anyone taking these supplements having Parkinson’s-like symptoms. Not one. And the next study they published a year later proved it.

This one was just as convoluted in my personal opinion, but I need to discuss it because it refutes all prior studies of brain cell death/toxicity. Again, you can decide yourself. This time, they went in the lab to prove that long-term daily consumption of graviola fruit juice causes neurotoxicity. I’m just assuming graviola juice products had gained in popularity enough to target this then. But they didn’t use regular, normal mice for the study. They used mice that carried a genetic mutation in the brain which causes a weaker blood-brain barrier and the inability to clear out substances from the brain once it gets in the brain so it has a build-up/residual effect. This genetic mutation isn’t very common in humans and is present in a very small percentage of people, living mostly in Northern Europe and Japan. The mutation also creates more of a brain protein called tau. They justified using these mutated mice because MAYBE the nutritional deficiency in the West Indians could have POSSIBLY created a similar condition (weakened brain barrier and/or inability to clear substances from the brain) but this was never confirmed in the actual patients who had Parkinson’s symptoms who were cured by just fixing the nutritional deficiency. Convoluted? You decide. What I see in reading thousands of studies, is that researchers can easily set up their study protocols to prove exactly what they want to prove before the study even starts. Just my opinion, of course.

So, they gave one group of the mutated mice only graviola fruit juice to drink instead of water for an entire year. (!) Won’t take the time to go there. (sigh) They gave another group of mutated mice water to drink instead and compared the groups. The lifespan of a normal mouse is about 5 years (I haven’t bothered to looked up the lifespan of these mutated mice) but that would be about the equivalent of a human drinking nothing but graviola fruit juice instead of water for like 10 years or more. (Which of course, I would never do and you shouldn’t either.) If I believed the previous study of killing 67% of their brain cells with one dose, I would have assumed these mice wouldn’t have made it a year. But they did, and when they examined their brains after a year of this chronic use, there was no cell death in the brain, no astrocyte cell loss, no loss/death of dopamine-type cells or any of the other cell death claimed in all the other studies (that manipulated graviola or its main annonacin compound over the blood-brain barrier in some fashion – just as this study manipulated it over the barrier with the mutated gene causing a weakened barrier).

None. Nada. Zip. They also didn't see any "Parkinson's-like symptoms" in these mice (even the mutated mice) for the entire year the mice drank the graviola fruit juice.  What it did do was aggravate the genetic problem of too much tau (that isn’t present in MY brain) and caused some pro-oxidant damage to the excessive tau in their brains. There was also a little bit of oxidation in the non-mutated mice’s tau but no-where near the mutated ones. This oxidation, in my personal opinion, could possibly be related to drinking only fruit juice (any kind of fruit juice) instead of water for like 10 years, which might just cause some oxidative free radicals. Who would do that? Not me. This oxidation could also have been the chronic buildup (mutated barrier) and effect of the three chemical preservatives in the fruit juice these mice drank too. Again, if I have to say it, you shouldn’t do this either. Water is good for you; drink lots! Chemical preservatives can be bad for you; avoid them when you can and don’t take them chronically like that.

Several other studies have been published over the years about graviola and neurotoxicity but they were injecting graviola extracts (which contained various toxic extracting liquids) or just the isolated annonacin directly into the bloodstream (intravenously) to get it over the blood-brain barrier. One study even put it in one of those chemo or pain medication drug pumps that pumped it into the bloodstream continuously over 3 days. Some injected it under the skin or in the muscles, like a regular shot would. These studies all claimed neurotoxicity to various brain cells in their published research by manipulating the method to help get it over the blood-brain barrier. Again, nothing like what happens when someone drinks a tea, takes a capsule, or drinks some juice and it goes through the normal digestion process. And this mutated mouse study confirms the neurotoxicity these studies reported simply doesn’t happen when the leaf or juice is ingested (not injected).  They also proved the long-term consumption of graviola fruit juice does NOT cause Parkinson's-like symptoms in mice.

But studies still keep getting published that it does and that graviola is a neurotoxin. I won’t go there on why I think they are. Let’s just acknowledge they are and leave it at that.

One recent study again reporting neurotoxicity I read yesterday made me laugh out loud. Researchers have this mutated flat worm they use to determine if a plant or plant compound might be “anti-aging.” This worm is mutated in a special way, so that if you can prolong the short life of this worm with some compound or plant, it indicates you might possibly prolong the life of humans. I’ve seen a lot of this research using this worm on the Amazon plants I’m updating since it targets possible anti-aging compounds for further research. Anti-aging plants/chemicals/products/supplements are of great interest to researchers these days. Anyway, they exposed these mutated worms to a graviola extract. They produced about 20% fewer eggs and didn’t wiggle around quite as much. They said this was because graviola was “probably neurotoxic.” [insert laughter here] Graviola is used as an insecticide and it’s a documented antiparasitic (against various worms); I was shocked graviola didn’t kill these wigglers and wondered just how they had mutated them!! Before I found out about graviola and cancer, my main use of graviola was as an ingredient in my herbal remedy to kill parasites and worms. Several new studies continue to report that graviola can kill intestinal worms and parasites in animals and humans. 

So, let me summarize. The way I personally avoid all the documented/researched/published "brain toxicity" from graviola is: A.) I don’t extract it (especially in toxic liquids) and inject it into my brain. B.) I don’t go thru a complicated process to just extract annonacin from graviola and inject that in my brain either. C.) I never ever inject graviola or annonacin in any form directly into my veins or under my skin, or in my muscles either (or put it in a “pain-pump” to inject it into my bloodstream regularly over many days at a time). D.) And I never ever use or take graviola chronically every day. I am going to tell you why in another blog because I know some people are doing this. Go here to see why I think it isn’t necessary or helpful to do so. And btw, if I have to say it, I would advise you to not do A thru C above either. Sheesh!

I should probably take the time to remind everyone; graviola is a popular fruit in Brazil and throughout Latin America. The fruit is sold in markets and grocery stores, fresh and canned fruit juices are widely sold and the fruit is often prepared in ice creams, syrups, candy, shakes and other beverages. I can even find standard graviola fruit juice at my grocery store in Texas sold under the Spanish name, Guanabana with the rest of the canned fruit juices and nectars (unfortunately loaded with high fructose corn syrup).  Outside of the one isolated case in the West Indies that was proven to NOT be graviola, there has not been any outbreak of Parkinson's Disease, or Parkinson's-like symptoms any where in Brazil, Latin America or North America, for that matter, where graviola supplements have steadily gained in popularity.  An search I just did, linked to 542 products searching for "graviola supplements."

So, these are my personal opinions; you can do with them what you will and make your own personal choices about your health. Look up these studies on PubMed and read them like I did and form your own opinions about them. I haven’t shown any of the neurotoxic studies in graviola’s plant database file either for all the obvious reasons I’ve discussed. I believe these studies just aren’t applicable to how graviola is used as an herbal supplement today which is what my online plant database is about.

As always, stay tuned! More to come… Don’t forget to read why I personally don’t use graviola chronically/daily or for “wellness”“cancer prevention” or “immune health.”

Graviola as a Preventative?

First, I am sharing my personal opinions on this subject. My opinions are based on my own personal research I’ve conducted over many years on many rainforest plants, my use of them on myself and in my naturopathic practice, my use of them formulating herbal supplements, and twenty years of selling these herbal supplements and formulas in the world-wide natural products market to health practitioners and direct to consumers.  I no longer sell anything… no herbs, formulas or products. I have no financial ties to anyone who does sell herbal supplements. No one is paying me to say this, and no one can pay me not to say this.

Graviola kills cancer.
There, I’ve finally said it! I never could say it before because I once sold it. But I can today.
Wow, that feels good!

And what you need to be aware of, is that none of the manufacturers or companies selling graviola today can say this. They must make FDA-approved “structure-function statements or claims” like… “graviola supports a healthy immune system” and other unhelpful, and in my opinion, misleading statements and claims in marketing graviola (and most other herbal supplements). I want to clear up this confusion now because I can now.

I do NOT use graviola to help immune function. I do NOT use graviola as a daily supplement for cancer prevention or any other type of condition. I use graviola for cancer. These manufacturers selling graviola would tell you the same thing if they could. They are simply saying whatever is “permitted” to say.

This is what all the research says: graviola can kill cancer cells in several highly specific ways. It also has a way to specifically target cancer cells and kill those cells and not healthy cells. Lots of research has proven this; more research is continuing to prove this. I’m updating all the new research right now to update the plant database file on it. Stay tuned, because I’ll write a new blog very soon discussing this new cancer research on graviola – it’s epic!

One of the ways graviola targets cancer cells is liking and being attracted to a chemical called ATP. If all your cells are cars, ATP is the gasoline that fuel the cars. Your body makes its own ATP/gas out of a “crude oil” chemical called CoQ10. Not enough CoQ10 circulating in your body means not enough ATP fueling your cells. All of your cells have ATP in them and need it to function properly.

A cancer cell is like a high-octane-gas-guzzling speedy race car. It needs and uses LOTS more ATP because it’s rapidly growing and dividing much faster than normal cells. The anticancer compounds in graviola like, and are attracted to ATP, and migrate to these high energy/high ATP cells first. The second way graviola targets cancer cells is that there is a specific enzyme that is found only in the cell wall of some types of cancer cells that’s rarely expressed in normal healthy cells. It's not in all cancer cells, but it's in a lot of them. These graviola anticancer compounds are attracted to this enzyme and seek it out and find it too. Between the high ATP and this enzyme, these anticancer compounds in graviola naturally gravitate to cancer cells.

This is especially true for cancer cells that have mutated against chemo drugs to survive. The main way they mutate is by creating a tiny pump inside the cancer cell that can pump out the chemo faster than the chemo can kill it. Once these type of cells are formed and they divide and grow, they’re completely drug resistant because they all have these little pumps. BUT, running the pumps take even more ATP energy, so graviola compounds are especially attracted to these very high ATP/energy multi-drug resistant cells too.

Once these graviola compounds find a high ATP energy cell they almost completely inhibit the ATP in the cell. With the reduced energy, the cancer cells can’t run the high-energy pumps and they shut down. With the loss of fuel in the cancer cell, they can’t divide and multiply as fast and sometimes not at all. There’s just not enough fuel for these high fuel processes. The research shows this effect can stop the cancer cell’s ability to grow/make copies of itself. But the ATP inhibition doesn’t actually kill the cancer cell. Now that the compound is there, the enzymes in the graviola compound interacts with the enzyme in the cell wall of the cancer cell that graviola was attracted to. This interaction of the enzymes causes the cancer cell wall to dissolve or fall apart. That is one of the ways that these graviola compounds are actually capable of killing cancer cells.

If you DON’T have a bunch of these high energy cancer cells for graviola to migrate to, and you take a lot of graviola and take it chronically/daily, these compounds will start inhibiting ATP energy to healthy cells. It won’t be killing these healthy cells but they will start slowing down with less energy. That is the main reason I’ve never used graviola as a daily cancer prevention supplement. It’s also why I’ve never recommended to anyone to take it for longer than 30 days if they don’t have cancer. This is why I didn’t use it in any formula that would be used chronically, like the formula I had that actually did support your immune system that could be taken long term.

Graviola doesn’t “prevent cancer” it kills the cancer cells you already have. If you want a supplement that “prevents cancer” look for plants with “antimutagenic” actions. When a healthy cell starts to mutate into a cancerous one, the first thing that happens is the DNA strands break. You want something that prevents these breaks and might even be able to repair broken strands. Cat’s Claw has been documented with the ability to do this. So has Chanca Piedra. Graviola has not. Personally, I don’t know what will happen with chronic low cellular energy/ATP to a bunch of my healthy cells, and it’s not something I choose to find out by taking Graviola chronically in the absence of cancer. I just don’t need to.

That’s why I’m concerned when I see some of the “enforced marketing statements” on graviola products. I don’t use graviola for immune function and still won’t even after a couple of new studies were shown that it does help immune function.  Instead I use cat’s claw to support immune function.  It works better than graviola for this, it’s fine to take chronically/long term and it has none of the ATP inhibition issues that graviola does. I’m really glad to see graviola can increase some natural killer cells and help modulate some inflammatory immune chemicals as shown in some of the new research! That’s really helpful if you have cancer and are fighting it with graviola.

Some of the new research says graviola is a great antioxidant. But I won’t be using it in the new antioxidant I’m formulating now because of the ATP inhibition problem. I’m glad graviola has great antioxidant actions… once again, that’s VERY helpful if you are battling cancer and using graviola as one of your weapons. Look at the blog I wrote on cancer and antioxidants.  But if I didn’t have cancer, I would use cat’s claw or chanca piedra or several others as a healthy daily antioxidant. All three of these plants have the same exact common antioxidant chemicals that are commonly found in strong medicinal plants. I don’t want slow functioning or low energy cells in my body if I don’t need to.

Personally, what I do for cancer prevention is take one bottle of graviola (I actually like the formula I developed called N-Tense instead of graviola alone for this) at two capsules twice daily for one month. I personally do this twice a year hoping to just clean up any cancer cells I’m not aware of that might be floating around. Others I know who have other health issues that make them more prone to developing cancer for some reason, do this “prevention” 3-4 times a year. I certainly can’t prove it works this way for this purpose. It just seems logical to me based on what I know, and it’s what I do. I also see in the research, once the graviola is gone the ATP inhibition is gone and the cells quickly return back to normal energy levels.

Some of the new research on graviola is showing some benefits in diabetes and I’m seeing some marketers of graviola try to relay this information. Again, personally, I would not use graviola chronically to treat diabetes either for the same reason. The benefits recently shown that graviola provides for diabetes can be obtained from another plant called picao preto. That plant is fine for chronic use and provides the same types of benefits for diabetes and actually works better at it than graviola (based on recent animal studies on both plants).  Picao preto also is a great source of the same antioxidant chemicals in graviola, so I’d get that benefit too (and much of the “anti-diabetic” research on both plants are attributing this benefit to these antioxidant compounds anyway).

There are lots of other effective non-energy-depleting options for these things. I used graviola in two formulas, both used to be taken for around 30 days. One was for candida/fungus and the other was for parasites. Neither were meant to be taken chronically or for preventative purposes.

This also is true for graviola fruit juice and the fruit juice supplements being sold. My personal opinion is these should not be taken chronically either for all the same reasons. Personally, I always had some questions and mild concerns about the juice and I never sold it or used it. All the research supports that graviola seeds found in the fruit contains a couple neurotoxin alkaloids and the seeds should not be ingested for this reason. I’ve been to a couple of Brazilian juice factories and watched them process fruits into juice. Mostly they just put the whole fruits into a big machine that chopped them all up, skin, peel, seeds and all. They add water, stir it around for a while and then mechanically press out the liquid from the chopped-up stuff and it’s juice (then usually sweetened and bottled or spray dried into fruit juice extract powders). Some thicker, more bitter fruit peels of some fruits might get removed first to protect the taste of the resulting juice.

I always wondered if any of these toxic alkaloids in the graviola seeds leached out into the juice if the seeds got chopped up in this process, and if so, was there enough to be a problem. I know seeds are not removed before juicing graviola; they’re too wrapped around the pulp throughout the fruit to do this effectively. I always stuck to using graviola leaves because I didn’t want to have to deal with this potential problem. I will say however, after seeing a study on mice chronically drinking graviola fruit juice for a year (see the Graviola Safety Blog page) it doesn’t seem to be a big issue.

And this study proves my point. They did notice an ATP-inhibition effect in brain cells in this mouse study. It didn’t kill any brain cells, but they recorded less ATP in these healthy cells and suggested this lack of ATP might have caused the cells to oxidate more efficiently. They manipulated the graviola fruit juice over the blood-brain barrier by using mutated mice so this is probably not happening in our un-mutated brains, but it can certainly happen with juice products elsewhere in the body. For all the same reasons, I personally don’t recommend drinking graviola fruit juice chronically or taking any of the fruit juice supplements chronically either, for all the same reasons as above.

It’s your health and your decision however. I’d urge you to do some more research on graviola’s ATP-inhibition actions before you decide to continue taking it chronically long term. Consider taking a break for a couple days every week or so. If you choose to continue chronic constant use and you don't have cancer, it may be helpful to add a CoQ10 supplement to your diet. Remember, CoQ10 is the crude oil your body needs to make more gasoline/ATP. This is the opposite of what I do for cancer. I don’t want to fuel the cancer cells with more ATP and I want graviola inhibiting the ATP to those cells. But if you don’t have cancer, your healthy cells may need this added ATP starter chemical to overcome graviola’s action in this regard. Just something else you should consider as you make your own health decisions.

Stay tuned… I’ll be adding a new blog soon on all the new cancer research that has taken place on graviola when I finish updating the graviola Tropical Plant Database page for it.

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