Why Antioxidants Help You Lose Weight

I think this is my fourth blog article on antioxidants...  who knew antioxidants were that important!!

Most people have no clue that the fat in their body actually works like a metabolic organ… and it helps regulate just how easy or hard it is to lose weight and to maintain a healthy weight. If you’re overweight, it’s time to learn! Your fat may be making it much harder for you to lose weight… and causing you to fail to lose no matter what diet you try. And you probably don’t know that the solution to the problem is antioxidants!

Here’s why:

The fatty tissue in our bodies (medically called adipose tissue) is a loose connective tissue mainly composed of fat cells (medically called adipocytes). We have two different types of fatty tissues which are called brown adipose tissue (BAT) and white adipose tissue (WAT). BAT’s main function is generating heat and burning stored calories as energy in a process called thermogenesis.  That’s why BAT is often referred to as our “good fat.”  But too much of a good thing is never a good thing; even the good BAT can accumulate to high levels internally and cause problems.

WAT is the most abundant type of fat in our bodies and its main function is storing energy (and all those extra calories we eat that don’t get exercised and burned off is the “energy” we’re talking about). It’s mostly our padding layer and is found just under the skin. WAT is all the wiggly giggly stuff in our belly rolls, muffin tops, love handles and done-lops and it forms the base of that persnickety cellulite we all despise.  You might need to be from the South to know that “done-lop” is that annoying pooch of waist-WAT that “done-lops over your belt.”  WAT is basically all the fat we love to hate.   By the time you finish reading this article, you may learn to hate it even more, since it has probably been the biggest contributing factor on why it’s been so hard for you to lose weight!

WAT has been well characterized as an endocrine organ because it controls a wide range of biological functions including our metabolism. This “organ” creates a metabolic system of its own that can determine how hard or easy it is to lose weight. In addition to energy storage and heat production, fatty tissues and fat cells secrete a wide range of natural chemicals called cytokines.  These are collectively called ‘adipokines’ (adipose + cytokine).  These adipokines include pro-inflammatory protein substances as well as anti-inflammatory protein substances.  Adipokines play crucial roles in our bodies including controlling energy balance, hunger, glucose balance, immune regulation as well as creating new blood vessels, and regulating cardiac contractility just to name a few. Fat cells also produce hormone chemicals known for regulating blood pressure and fluid balance.  All in all, scientists have now discovered over 80 protein or hormone substances that are secreted by fat cells, many of which have known metabolic actions. Research has increased significantly on these natural fat-produced substances and their roles in obesity, diabetes, heart diseases and other disorders since 2010. New knowledge about these substances and their roles have encouraged the development of new drugs targeting this metabolic system in the treatment of obesity, metabolic diseases and heart conditions.

If you look at the fat of healthy lean individuals, the fat cells are small in size, fewer in number, they are insulin sensitive, and primarily secrete anti-inflammatory substances. By contrast, overweight individuals have fat cells that are large, the fat tissue is infiltrated by a large number of pro-inflammatory immune cells (called macrophages), and it secretes many more inflammatory substances and less anti-inflammatory ones. For this reason, “obese” fatty tissue is often referred to as inflamed, and obesity is now categorized as an chronic inflammatory disease. Low-grade inflammation in fatty tissue causes significant alterations or deregulations in the adipokines they secrete. Overweight and obese people live in a chronic low-level inflammatory state due to these deregulations. Since our fatty tissues and fat cells expand as we gain weight, all of these fat-secreted deregulations and resulting inflammation increases as our fat increases.  You don’t have to be obese either, just gaining some extra weight can start the process and head you down the road to deregulations.  These deregulations make it much harder to lose weight and some can make it virtually impossible to lose weight!

Why your fat might be keeping you fat

Your fat causes deregulations mainly in two ways.  Either you are secreting too many of some adipokines because you have more fat cells to make them and release them, or you aren’t secreting enough of other adipokines because the inflammation in the fat cells make it harder to produce and release them.  It’s not quite as simple as that, because the inflammation has the ability to set up self-perpetuating cycles that keep your fat sick and inflamed. So, let’s first look at fat inflammation.

Fat inflammation is created in three ways. When the fat cells do their main job of processing fats and sugars to store them in fat cells, a by-product of the process is another substance called a free radical or reactive oxygen species (ROS). The more we eat, more processing is needed and more ROS is created in the process.  ROS plays a beneficial roll in many other processes, but too much ROS is a big problem. When our built-in antioxidant system that normally controls ROS becomes overwhelmed by too much ROS, oxidative stress results and this oxidative stress causes inflammation and eventually results in cellular damage. Our fatty tissues and fat cells are very sensitive to oxidative stress and can become sick, inflamed and deregulated by not producing enough of certain adipokines as a result. It is now well documented that people who are overweight have much more ROS and oxidative stress than healthy weight people have, and the more overweight you are can directly relate to higher oxidative stress levels. But the real issue is some specific adipokines are actually doing the work of processing these molecules for storage and when there are too many or too little of these adipokines, then even more ROS can be generated and/or too much fat can be stored.

The second cause of inflammation are other ROS-like substances called advanced glycated end products, or AGEs for short.  AGEs are basically a sugar molecule that bonded to a protein molecule incorrectly. Normal sized fat cells are sensitive to insulin (which processes sugar in the diet).  The larger the fat cell grows as it stores more fat, the less sensitive it is to insulin. This interferes in how fat cells process sugar molecules and this can lead to more improper bonds and AGEs are produced. AGEs cause more ROS, can damage cells directly, and they’re well known to produce inflammation.  People who are overweight and/or obese have much higher levels of AGEs. The damage caused by AGEs (and oxidative stress) is now believed to be the leading cause of type 2 diabetes, metabolic syndrome, clogged arteries, and many heart diseases. This is why your doctor tells you to lose weight – to avoid these obesity-linked diseases because you have more ROS and AGEs than healthy weight people have.

The third cause of fat inflammation is our immune system. When injury or cellular damage occurs in our bodies it’s our immune system’s job to repair the damage or remove unrepairable cells to make room for new ones.  Many of the chemicals and cells produced by the immune system are pro-inflammatory; inflammation is a natural immune response.  When fat cells are damage by oxidative stress and AGE’s the immune system can flood the fatty tissues with these inflammatory chemicals and it triggers some of the pro-inflammatory adipokines to increase in number. In fact, some of the cells that make up the immune system are, in fact, adipokines. Part of our immune system lives in our fat.  The result is a lot more inflammation in our fat which has a deregulating effect and inflammation can cause more ROS. This is why sick deregulated “obese” fat produces more pro-inflammatory adipokines and less anti-inflammatory ones – the immune system is driving this deregulation trying to repair damaged fat cells.

There are just too many adipokines that become deregulated in this process to explain them all, so we’ll look at just two as examples.  These two adipokines have a well-known effect on how hard or easy it is to maintain a healthy weight. These are also good examples how deregulations cause some vicious cycles between deregulation, oxidative stress and inflammation and keeps your fat, keeping you fat.  The first is an adipokine called leptin and it’s a good example of too much fat producing and releasing too much of an adipokine.
  
One of leptin’s main roles is controlling appetite which helps determines how much we eat. As our fat expands, we actually produce more and more leptin, which you’d think would be a good thing.  Unfortunately, it isn’t.  Just like too much sugar causes too much insulin which results in insulin resistance, too much leptin produced by too much fat promotes leptin resistance. Chronic inflammation also helps create leptin resistance and too much leptin also produces more inflammation. Leptin is actually one of those pro-inflammatory adipokines. Most obese people are leptin resistant, and even being moderately overweight can result in leptin resistance. Once we lose leptin resistance, we can stay hungry all the time and we usually eat more than we really need to and it make eating less when dieting much harder. Moreover, leptin plays a role in how proteins, sugars and fat molecules are processed right before storage in fat cells.  This means too much leptin can result in better/more processing and more molecules/calories are stored as fat in these cells instead of burned as energy.  Leptin also plays a role in the immune system as it participates in the activation of immune cells called monocytes and macrophages which can invade the fatty tissues and cause inflammation and the generation of more ROS. Do you see the self-perpetuating cycle here and how this one adipokine can make weight gain easier and weight loss harder as the inflammation, ROS, and immune system go round and round?  Not to mention it makes you hungrier and stores more fat!  Wow, huh?

The next example is an adipokine named adiponectin and it is a good example of  fat cells under the stress of inflammation not producing and releasing enough of an adipokine.  Adiponectin is the most abundant adipokine produced in our fat cells and it is one of the anti-inflammatory substances produced in our fat. When our fat tissues and cells come under oxidative stress and inflammation, adiponectin levels are greatly reduced. Adiponectin levels are decreased in people with obesity, insulin resistance, and type 2 diabetes (all of which have much higher levels of ROS, AGE’s and resulting inflammation), Adiponectin helps break down and metabolize fats and sugars in the liver and exerts insulin-sensitizing, anti-inflammatory, and immune modulating actions. If our fat cells and other cells start losing insulin sensitivity, the lack of adiponectin (and three other adipokines) are playing a role. Don’t forget, insulin resistance leads to more AGEs being formed and more AGEs means more inflammation and ROS!
  
Just looking at just these two adipokines reveal the deregulations that can occur when we begin gaining weight. By the very nature of how these two work, and what kinds of roles they play, gives us a better understanding how deregulated fat begins to  keep us fat and promote more weight gain. However, don’t forget, our fat is producing over 80 different adipokines playing many roles and these are just two! Much more is going on in our fat that isn’t being discussed here, much of which are now shown to be leading causes of chronic diseases.  The self-perpetuating cycles between the immune system response to AGEs, oxidative stress and cellular damage by ROS are all maintaining a chronic inflammatory state which keep these deregulations settled into a “new normal” state for people who are overweight. Losing weight with all these deregulations isn’t easy.

The MUCH easier way to lose weight is to treat the deregulations by treating the inflammation first. This represents a brand-new and effective weight loss strategy that many people just don’t know about yet.  Drug researchers know however; some creative drug companies are re-evaluating their anti-inflammatory drugs as possible candidates to re-brand into new weight loss drugs. They know relieving inflammation in the fat will create weight loss by fixing some of these deregulations. If it weren’t for those pesky side effects of some of their drugs being used long term… and they’d need to be used long term, since they aren’t addressing the actual cause of the inflammation.
  
That’s where natural antioxidants come in!  In fact, most every natural antioxidant plant chemical has also shown to be anti-inflammatory. In many cases, it is actually relieving inflammation by reducing oxidative stress. Some rainforest plants I’ve been studying also have antioxidants that also reduce the formation of AGEs. Reducing AGES, ROS, and the resulting oxidative stress and cell damage will cool off the immune system and all of the inflammation by all of these causes will abate. This addresses one of the root cause of weight gain and it will help you fix the deregulations that have been silently working against you and making it harder to lose weight.

Stay tuned for more… I’ll be uploading a new plant in the online plant database soon that has human studies on both weight loss and its strong antioxidant actions.  I’m currently rewriting a database file on an existing rainforest plant with new studies on weight loss and it too is a strong antioxidant!   It’s some exciting information that I think will help lots of people not only lose weight; it will help them maintain their new weight much easier as well! All this new information makes developing a new rainforest antioxidant formula much more important, and I’m working on that one too!

What Every Diabetic Needs To Know About Antioxidants

Antioxidants versus Cellular Protectors

There is a generally accepted idea in the marketplace that good antioxidants come from fruits and vegetables and that these natural antioxidants scavenge free radicals in the body that causes damage, disease and aging. Fruit and vegetable concentrated extracts are sold as supplements to counteract poor diets that don't include enough fresh fruits and vegetables. These are mainly marketed as "rich in antioxidants which will scavenge free radicals." Demonstrations of free radical scavenging in test tube measurements by antioxidants and animal and cell culture experiments of imposed oxidative stress proving damage to cells, has contributed to this generally accepted idea. Thus the universal idea (and marketing concept) evolved  that since free radicals produce damage and antioxidants scavenge free radicals, antioxidants must be health protective because they quench free radicals. Thus, it was presupposed that the more antioxidants one could pack into cells and tissues, the greater would be the resistance to pathology caused by free radicals.

This subsequently primed the development and implementation of scientific measurements of the capacity of both pure plant chemicals and plant extract samples to quench free radicals in test tube studies. Such studies have flooded the scientific literature for the past two decades. In these experiments, different radicals produced in vitro are reacted with molecules or chemicals present in the plant sample under scrutiny. One can then measure either the extent to which radicals are ‘quenched’ or the kinetics of the oxidation of a reported molecule, as altered by the ‘antioxidant’ under study. By such methods, both plant extracts and thousands of phytochemicals have been shown to have ‘significant’ free radical scavenging and/or antioxidant capacity. Researchers also determined other plant polyphenols from medicinal plants had 4 to 5 times the antioxidant capabilities and/or were efficient at much lower dosages in vitro than the standard vitamins E, C, and A antioxidants.

Awkwardly, the concept of free radical scavenging by supplemental antioxidants has been challenged in at least four clinical studies in higher animals and in human clinical trials. [1, 2, 3, 4] It has been demonstrated pretty clearly that the in vitro antioxidant effect did not have the same effect in vivo when measuring free radicals in study subjects. The exception was high dose a-tocopherol (vitamin E) in the prevention of cardiovascular disease [5]. Based on these studies, mainstream medicine has largely deemed antioxidants as worthless or over-hyped products sold as nutritional supplements with little to no benefit. This is largely true if scavenging free radicals is the standard by which  antioxidants are judged. Because they don't, or at least not very effectively at all.

Research on antioxidants has gone much beyond scavenging free radicals and this information is simply unknown in the consumer market, and even in some regards, in the natural product manufacturer’s knowledge. Research beginning in the early 2000s began reporting that antioxidants’ main method of action was NOT scavenging free radicals, but they were actually interrupting the complicated chain of events that happen in the intercellular processes the body uses to create a free radical.[6] The terms “chain-breaking antioxidants” and “termination-enhancing antioxidants” were coined and research methods to quantify and measure those effects began to be developed. These compounds supposedly now prevent the formation of free radicals rather than remove or “quench” already formed free radicals.  Once again, there were some differences between in vitro measurements/effects and those demonstrated in in vivo in animals and people. Some antioxidants worked in this manner (here's one example), but again, not as well as in vitro results (too many radicals everywhere which too few antioxidant molecules couldn’t reach). There is little consumer knowledge regarding these principles and effects which are complicated and hard to explain to the lay person why one antioxidant works and another doesn’t.

Since a “free radical scavenger mechanism” for nutritional antioxidants cannot be completely substantiated on a kinetic basis in vivo , (whether it scavenges them or reduces the formation of them) what then accounts for the therapeutic effect and benefits of some of these polyphenol antioxidant compounds (like vitamin E and heart disease) used in various diseases and conditions? Studies over the last decade demonstrate that many of the so-called ‘antioxidants’ provide cellular and tissue protection against oxidative damage by inducing the body’s natural antioxidant defenses (ie. superoxide dismutase, glutathione and others chemicals the body produces to fight free radicals more effectively) and through modulating signaling messages between these molecules. Thus, a variety of compounds, including polyphenols, which can act as chemical antioxidants in vitro, have been shown to actually induce enzymatic systems in vivo. So now these antioxidants aren’t scavenging free radicals, they aren’t preventing the formation of them, they are signaling the immune system to create more of it’s own defensive antioxidant chemical to fight them more efficiently.

So now they needed a new method to quantify and qualify these enzyme-catalyzed oxidative processes in vivo and they focused on the oxidation of fat.  Outside the body, when fats and oils are oxidized by oxygen they become rancid.  The oxidation of fats and oils inside the body is called lipid peroxidation. This process in the body involves fats reacting with oxygen producing hydroperoxyl radicals though a different complicated chain of events. Researchers confirmed lipid peroxidation is inhibited by phenolic antioxidants quenching lipid radicals propagating the chain reactions, and by reduction of lipid hydroperoxides from which radicals are continuously generated.

In some of these in vivo studies researchers were reporting that the antioxidants weren’t scavenging free radicals, they weren’t preventing the formation of free radicals, they were actually protecting cells from the oxidative stress that should have happened when the chain of events occurred, mostly through chemical signaling of the molecules in the chain reaction.

The first report of an antioxidant compound curing a disease through the inhibition of lipid peroxidation occurred in 1992 when vitamin E was used to protect liver cells from chemical damage and reverse cirrhosis.[7] One can also understand vitamin E’s effect on the heart in the previous antioxidant research confirming heart benefits. It wasn’t until much later that scientists discovered why and about the mechanism of action through the signaling effects disrupting the chain of events.

If specific antioxidants (and not all plant chemicals which have in vitro antioxidant actions have this ability) can prevent damage to cells, from specific things known to damage them, that’s a big deal! And it’s something that the marketers and manufacturers of these products aren’t allowed to tell you (but I can!).  A good example of this is the antioxidant glutathione, one of the natural compounds produced in the body as a part of the endogenous antioxidant defense system that gets stimulated in the first signaling modification.  Research conducted on this compound demonstrated that supplementing with extra glutathione had a cellular protective effect by preventing the damage from oxidative stress that should have been incurred when chemicals were introduced to the brain and the heart.  Manufacturers of this supplement knew what this meant but the only thing they could say under FDA regulations was the unhelpful structure/function claims of “supports healthy heart function” and “supports healthy brain function” in their marketing of glutathione supplements. These FDA mandated statements are false and misleading and gave consumers no clue that what it really did was completely protect brain cells and heart cells from damage from substances known to damage them.

So I am going to coin a new term and call these plant compounds and natural chemicals with these abilities and actions “Cellular Protective Antioxidants” and use that in my books, website and blog. Hopefully it will catch on.  It will certainly help consumers find the most powerful antioxidants that are providing these actions in living organisms like animals and people. These types of cellular protective antioxidants (most of which come from plant polyphenols) were also those being used to completely protect cells and organs from strong toxic chemotherapy drugs that I blogged about last week in OMG, Cancer & Antioxidants that a normal vitamin antioxidant could never achieve.

Over the last five years, many previously documented antioxidant plant chemicals and plant extracts have been tested to see if they are capable of inhibiting lipid peroxidation in vivo, initially to confirm the compound’s in vitro antioxidant action. When successful, and researchers noticed that these compounds evidenced strong cellular protective effects, protecting cells and organs from oxidative damage that should have occurred, research continued.  Some of these plant extracts and most all active plant chemicals found in these extracts that demonstrated this ability went on to other animal studies to determine if this cellular protective effect extended to other harmful chemical agents and/or diseases harming other organs and cells.

In all this research conducted on plant extracts and their chemicals some remarkable cellular protective discoveries have been made.  Many of these polyphenol cellular protective compounds have been isolated in rainforest plants, which is why I have been recently exposed to so much of this research as I update the research on the rainforest plants.  Just like glutathione is part of the intercellular human defense mechanism against free radicals and oxidative stress, polyphenols are part of a plant’s intercellular defense mechanism against oxidative stress.  Stress to plants include intense sunlight burning leaves and fruit, high heat and humidity stressing the plants, healing wounds, and fighting off or repairing the damage caused by numerous species of bacteria, mold, fungi, soil viruses, and insects prevalent in the species-rich Amazon rainforest. Rainforest plants produce an abundance of cellular protective polyphenols chemicals just to survive in the species-rich Amazon.

As I am researching and reading the latest research on the Amazon plants and come across new cellular protective antioxidant plants and chemicals,  I am setting these studies  aside  with the intent to formulate a broad spectrum “cellular protector” formula of rainforest plants that I can use in my protocols.  Protocols for cancer, diabetes, aging, and other chronic diseases which all need some type of cellular protection.  Maybe I can  even get a herbal supplement manufacturer to produce this formula  and sell it.  Some of these rainforest plants are providing incredible cellular protective actions in the animal studies I’ve read, including for diabetes!

Now. . . What Diabetics Really Need to Know

I have something for diabetics to use in the meantime... and it’s a polyphenol cellular protective antioxidant from a South American tropical plant.

It’s coffee!  No, really. I mean it.

First, now that you know what a cellular protective antioxidant is, do some research (if you don’t know) on why oxidative stress and chronic inflammation is probably the underlying cause of Type 2 Diabetes.  You’ll also quickly see oxidative stress and inflammation is the main cause in the progression of diabetes and the many complications and co-diseases so prevalent in diabetes.  You can start with these:
Why chronic inflammation leads to the progression of diabetes and its complications: Abstract
How addressing oxidative damage can treat diabetes and many diabetic complications: Abstract


One of the best antioxidants for diabetes that addresses both of these issues is found in coffee:

There are two very common polyphenol acids found in many fruits, vegetables and medicinal plants called caffeic acid and quinic acid.  When these two chemicals react with one another (or other chemicals, substances, or get activated to defend the plant from something), they create new chemicals which are basically combinations or bonds between these two plant chemicals. These bonds form new unique plant chemicals that are called isomers of these two chemicals.  One very well known isomer is called chlorogenic acid which I’ll call CGA for short.  This chemical (and it’s parent, caffeic acid), has been proven to have strong cellular protector antioxidant actions in vitro and in vivo, as well as anti-inflammatory, anticancerous, antibacterial and antiviral actions. The richest source of CGA and caffeic acid just happens to be coffee beans. Green un-roasted beans have more CGAs than the roasted/brewed beans do.

It's because of these CGAs that drinking coffee and green tea are now good for you. It wasn't too long ago that doctors told us coffee was to be avoided due to the negative effects of caffeine to the liver. They were wrong (again). Now coffee drinkers have shown to have fewer cancers and live longer. Recent research reports mounting evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day.

And, it’s all about the CGAs.

There has been a great deal of research on CGAs being beneficial for diabetics... both to help manage blood sugar levels and improve insulin resistance, as well as to provide the cellular protective actions against the damage and complications to heart, kidneys, nerves, arteries, and liver regularly seen in diabetes. And, CGA’s anti-inflammatory actions help reduce the chronic inflammatory state most diabetics experience which is also implicated in the progression of the disease.  This news hasn’t been widely disseminated and many diabetics have never heard of it.  For years, there weren’t any CGA health supplement products to buy either - so if you heard about it, you just enjoyed drinking more coffee.

Then BOOM, someone does an animal study that says that CGA promoted weight loss and burned fat in rats and mice and almost overnight, dozens of green coffee bean supplements rich in CGA are available to purchase everywhere. Go figure, huh?

Well, I am adding a green coffee bean supplement to my diabetes protocols, but not for weight loss. In fact, I think the dosages they are promoting for weight loss are too high (based on actual studies) and it would probably achieve weight loss better at lower dosages.  For sure, the labeled dosages are too high for diabetics.  Animal and human studies (and my own research on some rainforest plants that contain CGA and several other isomers) indicate CGAs work very well at low dosages. It also clearly shows when much higher dosages are used, the beneficial effect is minimized, lost completely, or it produces the opposite effects. You can see that readily in the studies in humans for high blood pressure detailed below.

So here are just some the studies to look at that will show you why I was convinced to put CGA in my diabetes protocols:


Human Studies on diabetes benefits:

Overweight men taking 1 gm CGA reduced glucose and insulin concentrations (0.7 mmol/L and 73 pmol/L, respectively Abstract (Note, I think the effect would have been MUCH better at lower dosages)

CGA modulates glucose uptake and gastrointestinal hormone and insulin secretion in humans: Abstract

Plasma glucose and AUC were significantly lowered (and note lower dosages of CGA were better. Abstract

Animal Studies on diabetes:

CGA protected rats from chemically induced diabetes and in 45 days returned all diabetic markers to normal: Abstract

Diabetic mice given metformin with CGA which inhibited hepatic glucose-6-phosphatase expression and activity, decreased hepatic steatosis (fatty liver), improved lipid profiles and skeletal muscle glucose uptake, which improved fasting glucose levels, glucose tolerance, insulin sensitivity and dyslipidemia: Abstract

Diabetic rats supplemented with CGA for 15 days normalized blood glucose levels, decreased lipid peroxidation levels of main organs and significantly enhanced wound healing: Abstract

In mice with late diabetes CGA lowered the levels of fasting plasma glucose and HbA1c and improved kidney fibrosis: Abstract

CGA improved high fat diet-induced hepatic steatosis (fatty liver) and insulin resistance in mice: Abstract


As I said above, many diabetic complications and progression of other diseases (heart, kidney, nerves, etc) are caused by oxidative stress and/or inflammation. Diabetic rats and mice experience the same diabetic complications and disease progression as humans do and many of these complications have already been reported in animals studies. I believe after reviewing these studies and more, CGA and other isomers might help diabetics avoid many of these complications. For example, diabetic neuropathy is caused by inflammation and oxidative stress and if you look at this study on the causes of neuropathy and then compare it to CGA's immune modulation anti-inflammatory studies below, you can see that CGA modulates almost all of the many enzymes, molecules, transduction signals and other processes related to this diabetic complication. This is showing to be accurate for other complications and co-diseases as shown by the below cellular protective actions documented in the CGA studies below.


Animal Studies on the Cellular Protective actions of CGA:

Protected the eyes of rats from diabetes-related cataract formation: Abstract

Protected the eyes of mice from diabetic retinopathy: Abstract

Protected diabetic rats from necrosis and increased wound healing Abstract

Protected the brains of mice and prevented chemically induced neuropathy: Abstract

Relieved neuropathic pain in diabectic rats: Abstract

Protected diabetic rats from anxiety and memory loss Abstract

Protected diabetic rat kidneys from oxidative stress in diabetic nephropathy: Abstract

Caffeic acid protected rat kidneys from chemical induced damage and inflammation: Abstract

Protected liver from developing steatosis (fatty liver) in rats fed a high cholesterol diet: Abstract

Reduced blot clots significantly (platelet aggregation) in diabetic rats: Abstract

Protected the livers of mice from liver inflammation and fibrosis: Abstract

Protected mice from diabetic sensorineural auditory dysfunction: Abstract

Protected endothelial cells in the heart and reduced hypertension: Abstract

Protected the brains of mice and prevented chemically induced amnesia: Abstract

Protected guinea pig skin against UV-induced oxidative damage: Abstract

Protected GI Tract from a ulcerative chemical in mice: Abstract

Protected livers of rats from damage/failure induced by methamphetamine: Abstract

Protected mice from common species in the gut that are prone to mutate into cancer: Abstract

Confirms in vivo antioxidant action by protecting mice from ischemia-reperfusion injury
(injury/oxidation of tissues by removing blood supply then suddenly returning it) Abstract

Protected the livers of mice from ischemia-reperfusion injury confirming anti-inflammatory and antioxidant actions in vivo: Abstract

Protected the bone marrow of mice from radiation damage: Abstract



Anti-inflammatory Action of CGA:

How CGA reduces inflammation thru immune modulation in vitro: Abstract and Abstract

Confirming in vitro immumomodulatory anti-inflammatory effect in vivo:

Protected the livers of mice from liver inflammation and fibrosis thru immune modulation of inflammation: Abstract

Modulated immune anti-inflammatory response in mice with pleurisy. Abstract

Modulated immune response in rats with induced rheumatoid arthritis: Abstract

Reducing inflammation in mice with colitis: Abstract

Reduced GI tract inflammation in mice: Abstract

Protected rats with spinal cord injuries from inflammation. Abstract

Many more studies on the anti-inflammatory action of CGA can be found here.



Human and Animal Studies on Lowering Blood Pressure:

Healthy subjects were given 400 mg of CGA reported decreased SBP and DBP (-2.41 and -1.53 mmHg, respectively) Abstract

Healthy subjects were given 450 or 900 mg of CGA reported no decrease in SBP and DSP. Abstract

Mild hypertensive subjects given 93 mg CGA reported decreases of SBP and DBP (4.7 and 3.2 mmHg, respectively): Abstract

Mild hypertensive subjects given 140mg CGA reported decreases of SBP and DBP (6.9% and 7.7%.): Abstract

Protected rats from developing high blood pressure by modulating activities of key enzymes: Abstract

Lots more animal and in vitro studies here.



Cholesterol Lowering Actions in Animal Studies:

In obese mice CGA and caffeic acid significantly reduced plasma free fatty acids, triglycerides, and cholesterol, and significantly increased HDL-cholesterol/total cholesterol ratio compared to a high-fat control group. Abstract

In rats fed a high fat diet CGA suppressed increases in serum lipid levels. Abstract

In rat fed a high cholesterol diet CGA (10 mg/kg) significantly reduced total and LDL-cholesterol, increased HDL cholesterol, and improved both the atherogenic index and the cardiac risk factor. Abstract



Anti- Obesity Actions in Animal and Human Studies:

In obese mice, chlorogenic acid and caffeic acid significantly reduced body weight, visceral fat mass, plasma leptin and insulin levels, triglycerides in liver and heart, and cholesterol in adipose tissue and heart compared to the high-fat control group. Only chlorogenic acid significantly lowered triglyceride contents in adipose tissue. Abstract

CGA decreased diet-induced obesity in rats by modulating PPAR and LXR transcription. Abstract

Healthy men and women demonstrated better fat utilization with CGA: Abstract



In vitro AGE-inhibitor actions:

Kim, J., et al. "Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking." Arch Pharm Res. 2011 Mar; 34(3): 495-500.
Do an internet search on "advanced glycation end products and diabetes" and learn what they are and how they affect the progression of diabetes and diabetic complications. Start with this study: Abstract
CGA has shown to inhibit the production of AGEs in the test tube. It has not been confirmed in humans or animals. It might be like antioxidants "scavenging free radicals" and just not work the same way in humans as it does in the test tube. We don't know that yet but it would just be icing on cake with all the other benefits of CGA shown above if it in fact did work the same way. The good news is that you can reduce AGEs in your diet, many times, just by changing the way you are cooking your food. This is a good book which will tell you how.



In vitro Anticancerous Actions:

Protected cells from mutation (cancer preventative): Abstract

oral cancers: Abstract

liver cancer Abstract

brain cancer Abstract

estrogen positive breast cancer Abstract

leukemia Abstract

In other in vitro studies CGA has demonstrated antibacterial and antiviral actions. There are lots of other studies reporting in vitro antioxidant, cellular protective, and antidiabetic actions that are just too numerous to list. If you want more, follow this link and start reading.


Rainforest Plants with CGAs

Rainforest plants in the Tropical Plant Database which contain chlorogenic acid as one of it's active plant chemicals include: Yerba mate (green, not toasted, leaves are up to 10% CGA), condurango and artichoke contain chlorogenic and caffeic acids. Cat's claw, macela and embauba contain CGA and other CGA isomers. Many other rainforest plants have other isomers of CGAs, even some unique ones never seen before. Studies like this are being published on various rainforest plants confirming CGA and/or its isomers, and even synergistic actions with other chemicals in the plant providing remarkable cellular protective effects in animals studies (in very low quantities). When researchers are testing a plant extract in animals and notice a particular activity of the extract (anti-diabetic, anti-obesity, anti-inflammatory cellular protective actions and others) then they perform the same tests on some of the extract's chemicals. Many of these demonstrated actions are being attributed to various known CGA isomers (not present in coffee beans) as well as these isomers in conjunction with other plant chemicals present in the plant extract.


Diabetes Protocol:

Until I have a better source of CGAs with the right dosages and other isomers with cellular protective actions, a green coffee bean supplement is going in my diabetes protocols at dosages of 200mg of CGA daily for individuals that weigh up to 180 pounds. Increase dosages for heavier weight individuals (50 mgs for every 40 pounds more). Do make sure to check your blood sugar levels several times a day when you first starting taking this supplement until you know how your body reacts to it. It has shown in humans and animals to lower glucose levels and your diabetes medication may need adjusting.

There are many green coffee bean supplements to choose from. Do find one that guarantees or standardizes their product to the amount of CGA so you know how much CGA you're getting per capsule/pill . Look for ones that are 400mg capsules with 50% CGA - these will deliver the 200 mgs of CGA. You don't really need the caffeine for the antidiabetic benefits studied above so if you are sensitive to caffeine, buy one of the decaffeinated green coffee supplements available. The caffeine is probably contributing to the weight loss effect, so go with a caffeinated supplement if you want to try and achieve that "side effect." You can find plenty of these supplements to choose from online and on amazon.com

Please come back here and tell us about your results... especially if you are achieving weight loss at these lower dosages. I would love to hear the feedback!


Enjoy!

OMG! Cancer and antioxidants. At last!

So, I just finished the 6^th plant I’ve researched and updated and it was the 3^rd plant out of the 6  that I’ve seen clinical studies where researchers or pharmaceutical companies are combining either the plant or chemicals extracted from the plant with standard chemotherapy drugs.

 Oh. My. God!  What are they thinking!!! 

It appears what mainstream medicine has finally learned (that I’ve been telling them since 1996 when I first launched cat’s claw) is that great antioxidants from plants offer remarkable cellular protective actions to healthy cells under the onslaught of indiscriminate chemo drugs that kill everything in their path. It's the good ole “burn the barn down to kill the rat in the barn” approach they’ve done for so many years. Mainstream doctors once thought that a cellular protective antioxidant like cat’s claw would protect a cancer cell from being killed by their chemo drug and warned all their cancer patients NOT to take any kind of antioxidant.  Doctors have warned cancer patients for many years now that all antioxidants would reduce the effectiveness of their chemo/radiation/treatment/results.  This made my eyes roll back in my head and put me in an untenable position of trying to tell a cancer patient that they should listen to me and not their oncologist.  

They were wrong.  I told them so, but most didn’t listen.  Cat’s Claw was a strong antioxidant and an immune stimulant proven in Germany and Austria to enhance the effect of chemo, protect healthy cells from damage, and keep the immune system intact in cancer patients undergoing chemo so doctors could administer even more chemo.  A cat’s claw extract was actually sold as an herbal drug in Germany by prescription only as an adjunctive cancer therapy for those exact reasons. American doctors didn’t want to hear it and they didn’t believe it. They started writing papers, articles, pamphlets, and clinical studies with questionable methods saying antioxidants are contraindicated in cancer.  But they certainly didn't tell their cancer patients to avoid eating fresh fruits and vegetables which are the main source of natural plant antioxidants in our diet.

I need to figure out what changed, because it’s obvious they see the truth now.  I’m assuming they just decided to “go with the flow” since so many Americans were using natural products and remedies without their doctor’s permission or advice and the doctors’ couldn’t ignore the results their patients were getting with them. Maybe it was the oncologists in Europe who had the ability to prescribe herbal drugs with antioxidant actions continually reporting the benefits in reducing toxicity for almost seven years now? What about all the product-sponsored research that now says that coffee and dark chocolate are good for you?  Both are good sources of plant-based antioxidant chemicals and these are the reasons they are now good for you instead of bad for you!

For about 5 years now, it looks like doctors, researchers and pharmaceutical companies worldwide, including in the U.S., are studying and clinically confirming now that plant antioxidants can prevent their toxic chemo drugs from killing liver, renal, brain, heart, blood, gastric, and immune cells. Antioxidants can also clean up all the mess left behind when the chemo drugs are killing cancer cells (scavenging free radicals created in the cellular dying process which damage other healthy cells in the vicinity). They are reporting some antioxidants in these published studies are making their chemo drugs more effective, not protecting cancer cells. Has mainstream medicine finally turned a corner? Not one of the many studies I've read thus far reported that antioxidants were protecting cancerous cells and they've been studying and looking for that effect as well.  I anticipate reading many more of these studies as I continue to update the research on all the rainforest plants - there are lots of strong antioxidants in rainforest plants!  Wow, huh?  

I hate people who take such glee in saying “I told you so.”  So, I’m just going to say. . .  “Neener. Neener. Neener. Dammit!”

But it’s of little wonder, and about time. My personal experience with cancer, and working with some of the cancer patients I’ve helped in the last 20 years, demonstrated to me that oftentimes the chemo will kill you faster than the cancer will. I almost died of renal failure caused by the chemo drugs used to treat my AML leukemia way before the leukemia was actually life threatening. A friend (and sort of family member) died a little over a year ago from ovarian cancer.  Let me restate that; she died of the toxicity to her heart that was caused by the doxorubicin chemo drug they gave her to treat her ovarian cancer.  This chemo drug is well known to cause heart damage.  It’s well known to cause death from the heart damage causing acute heart failure (which you have to sign a medical release for saying they told you that). But my friend's death was recorded as death from ovarian cancer, not death by chemo drug.  Sadly, this heart-toxic chemo drug has never once cured ovarian cancer.    It almost broke my heart when I was reading the clinical research showing a chemical in one of my beloved rainforest plants (a chemical called vitexin that comes from amor seco) completely protected the heart from this exact same chemo drug.  Also knowing that there was enough of this particular chemical in the plant to be effective to avoid this toxic effect to her heart. . .  I wish I would have started updating sooner.

So, are we seeing a paradigm shift in oncology?  First the relatively new (mostly non-toxic) immune therapies for cancer and now the antioxidants.  Have they burned enough barns down to make the shift?  Or maybe it's more and more cancer patients saying; "Now wait just a minute. . . you want to burn the barn down to kill a rat; you're kidding me, right?"  We’ll see.  Maybe I’ve just been away from all this too long playing on my farm and am unaware of a bunch of new antioxidant drugs in development?  I’m just so cynical when it comes to the very profit-driven drug industry. Well, I’m back, so we’ll see about that too!  

So keep an eye out on the updates I’m writing concerning cancer drugs combined with rainforest plants and/or their chemicals.  The number is 3 out of 6 so far. I think you’ll also see me reporting repeatedly that great plant antioxidants are providing very beneficial actions in many other diseases as well.  Diabetes for sure, heart diseases probably, skin and cellular aging absolutely, autoimmune diseases -  we’ll see!